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Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke.

ABSTRACT: BACKGROUND:The serum level of osteoprotegerin (encoded by OPG or TNFRSF11B) was previously shown to be increased in patients with ischemic stroke. A single nucleotide polymorphism rs3134069 in the TNFRSF11B gene was previously associated with ischemic stroke in a population of diabetic patients in Italy. It remains to be determined whether rs3134069 is associated with ischemic stroke in the general population or populations without diabetes. MATERIALS AND METHODS:We genotyped rs3134069 and performed a case-control association study to test whether rs3134069 is associated with ischemic stroke in 2 independent Chinese Han populations, including a China-Central population with 1629 cases and 1504 controls and a China-Northern population with 1206 cases and 720 controls. RESULTS:rs3134069 showed significant association with ischemic stroke in the China-Central population (P?=?9.24?×?10-3, odds ratio [OR]?=?1.50). The association was replicated in the independent China-Northern population (P?=?2.45?×?10-4, OR?=?1.53). The association became more significant in the combined population (P?=?7.09?×?10-6, OR?=?1.41). The associations remained significant in the male population, female population, and population without type 2 diabetes. Our expression quantitative trait loci analysis found that the minor allele C of rs3134069 was significantly associated with a decreasedexpression level of TNFRSF11B (P?=?.002). CONCLUSIONS:This study demonstrates that rs3134069 in TNFRSF11B increases risk of ischemic stroke by decreasing TNFRSF11B expression.

SUBMITTER: Xiong X

PROVIDER: S-EPMC6815228 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke.

Xiong Xin X Naji Duraid Hamied DH Wang Binbin B Zhao Yuanyuan Y Wang Junhan J Wang Dan D Zhang Yuting Y Li Sisi S Chen Shanshan S Huang Yufeng Y Yang Qin Q Wang Xiaojing X Yin Dan D Tu Xin X Chen Qiuyun Q Ma Xu X Xu Chengqi C Wang Qing K QK

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20180228 6

<h4>Background</h4>The serum level of osteoprotegerin (encoded by OPG or TNFRSF11B) was previously shown to be increased in patients with ischemic stroke. A single nucleotide polymorphism rs3134069 in the TNFRSF11B gene was previously associated with ischemic stroke in a population of diabetic patients in Italy. It remains to be determined whether rs3134069 is associated with ischemic stroke in the general population or populations without diabetes.<h4>Materials and methods</h4>We genotyped rs31 ...[more]

PMID: 29501268

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Project description:Although stroke centers are widely accepted and supported, little is known about their effect on patient outcomes.To examine the association between admission to stroke centers for acute ischemic stroke and mortality.Observational study using data from the New York Statewide Planning and Research Cooperative System. We compared mortality for patients admitted with acute ischemic stroke (n = 30,947) between 2005 and 2006 at designated stroke centers and nondesignated hospitals using differential distance to hospitals as an instrumental variable to adjust for potential prehospital selection bias. Patients were followed up for mortality for 1 year after the index hospitalization through 2007. To assess whether our findings were specific to stroke, we also compared mortality for patients admitted with gastrointestinal hemorrhage (n = 39,409) or acute myocardial infarction (n = 40,024) at designated stroke centers and nondesignated hospitals.Thirty-day all-cause mortality.Among 30,947 patients with acute ischemic stroke, 15,297 (49.4%) were admitted to designated stroke centers. Using the instrumental variable analysis, admission to designated stroke centers was associated with lower 30-day all-cause mortality (10.1% vs 12.5%; adjusted mortality difference, -2.5%; 95% confidence interval [CI], -3.6% to -1.4%; P < .001) and greater use of thrombolytic therapy (4.8% vs 1.7%; adjusted difference, 2.2%; 95% CI, 1.6% to 2.8%; P < .001). Differences in mortality also were observed at 1-day, 7-day, and 1-year follow-up. The outcome differences were specific for stroke, as stroke centers and nondesignated hospitals had similar 30-day all-cause mortality rates among those with gastrointestinal hemorrhage (5.0% vs 5.8%; adjusted mortality difference, +0.3%; 95% CI, -0.5% to 1.0%; P = .50) or acute myocardial infarction (10.5% vs 12.7%; adjusted mortality difference, +0.1%; 95% CI, -0.9% to 1.1%; P = .83).Among patients with acute ischemic stroke, admission to a designated stroke center was associated with modestly lower mortality and more frequent use of thrombolytic therapy.

Dataset Information

Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke.

Publications

Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke.

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