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?? T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity.

ABSTRACT: The innate and adaptive arms of the immune system tightly regulate immune responses in order to maintain homeostasis and host defense. The interaction between those two systems is critical in the activation and suppression of immune responses which if unchecked may lead to chronic inflammation and autoimmunity. ?? T cells are non-conventional lymphocytes, which express T cell receptor (TCR) ?? chains on their surface and straddle between innate and adaptive immunity. Recent advances in of ?? T cell biology have allowed us to expand our understanding of ?? T cell in the dysregulation of immune responses and the development of autoimmune diseases. In this review, we summarize current knowledge on ?? T cells and their roles in skin and joint inflammation as commonly observed in rheumatic diseases.

SUBMITTER: Nguyen CT

PROVIDER: S-EPMC6815259 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity.

Nguyen Cuong Thach CT Maverakis Emanual E Eberl Matthias M Adamopoulos Iannis E IE

Seminars in immunopathology 20190910 5

The innate and adaptive arms of the immune system tightly regulate immune responses in order to maintain homeostasis and host defense. The interaction between those two systems is critical in the activation and suppression of immune responses which if unchecked may lead to chronic inflammation and autoimmunity. γδ T cells are non-conventional lymphocytes, which express T cell receptor (TCR) γδ chains on their surface and straddle between innate and adaptive immunity. Recent advances in of γδ T c ...[more]

PMID: 31506867

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2006-01-24 | E-GEOD-4090 | biostudies-arrayexpress

Mechanism of the anti-inflammatory effect of colchicine in rheumatic diseases

2006-01-25 | GSE4090 | GEO

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