LINC01133 inhibits breast cancer invasion and metastasis by negatively regulating SOX4 expression through EZH2.
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ABSTRACT:
SUBMITTER: Song Z
PROVIDER: S-EPMC6815803 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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LINC01133 inhibits breast cancer invasion and metastasis by negatively regulating SOX4 expression through EZH2.
Song Zhiwang Z Zhang Xia X Lin Yun Y Wei Youzhen Y Liang Shujing S Dong Chunyan C
Journal of cellular and molecular medicine 20190926 11
Mounting evidence highlights long non-coding RNAs (lncRNAs) as crucial regulators in multiple types of biological processes and contributing to tumourigenesis. LINC01133, located in chromosome 1q23.2, was a recently identified novel lncRNA with a length of 1154nt. It was involved in the development of colorectal cancer and non-small cell lung cancer. However, its clinical relevance, biological functions and potential molecular mechanism in breast cancer are still unclear. In this study, we found ...[more]
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