Ontology highlight
ABSTRACT:
SUBMITTER: Matralis AN
PROVIDER: S-EPMC6816013 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Matralis Alexios N AN Malik Adnan A Penzo Maria M Moreno Inmaculada I Almela Maria J MJ Camino Isabel I Crespo Benigno B Saadeddin Anas A Ghidelli-Disse Sonja S Rueda Lourdes L Calderon Felix F Osborne Simon A SA Drewes Gerard G Böesche Markus M Fernández-Álvaro Elena E Martin Hernando Jose Ignacio JI Baker David A DA
Journal of medicinal chemistry 20191014 20
One of the attractive properties of artemisinins is their extremely fast-killing capability, quickly relieving malaria symptoms. Nevertheless, the unique benefits of these medicines are now compromised by the prolonged parasite clearance times and the increasing frequency of treatment failures, attributed to the increased tolerance of <i>Plasmodium falciparum</i> to artemisinin. This emerging artemisinin resistance threatens to undermine the effectiveness of antimalarial combination therapies. H ...[more]