Dataset Information

Measuring longitudinal cognition: Individual tests versus composites.

ABSTRACT:

Introduction

Longitudinal cohort studies of cognitive aging must confront several sources of within-person variability in scores. In this article, we compare several neuropsychological measures in terms of longitudinal error variance and relationships with biomarker-assessed brain amyloidosis (Aβ).

Methods

Analyses used data from the Wisconsin Registry for Alzheimer's Prevention. We quantified within-person longitudinal variability and age-related trajectories for several global and domain-specific composites and their constituent scores. For a subset with cerebrospinal fluid or amyloid positron emission tomography measures, we examined how Aβ modified cognitive trajectories.

Results

Global and theoretically derived composites exhibited lower intraindividual variability and stronger age × Aβ interactions than did empirically derived composites or raw scores from single tests. For example, the theoretical executive function outperformed other executive function scores on both metrics.

Discussion

These results reinforce the need for careful selection of cognitive outcomes in study design, and support the emerging consensus favoring composites over single-test measures.

SUBMITTER: Jonaitis EM

PROVIDER: S-EPMC6816509 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

Measuring longitudinal cognition: Individual tests versus composites.

Jonaitis Erin M EM Koscik Rebecca L RL Clark Lindsay R LR Ma Yue Y Betthauser Tobey J TJ Berman Sara E SE Allison Samantha L SL Mueller Kimberly D KD Hermann Bruce P BP Van Hulle Carol A CA Christian Bradley T BT Bendlin Barbara B BB Blennow Kaj K Zetterberg Henrik H Carlsson Cynthia M CM Asthana Sanjay S Johnson Sterling C SC

Alzheimer's & dementia (Amsterdam, Netherlands) 20190111

<h4>Introduction</h4>Longitudinal cohort studies of cognitive aging must confront several sources of within-person variability in scores. In this article, we compare several neuropsychological measures in terms of longitudinal error variance and relationships with biomarker-assessed brain amyloidosis (Aβ).<h4>Methods</h4>Analyses used data from the Wisconsin Registry for Alzheimer's Prevention. We quantified within-person longitudinal variability and age-related trajectories for several global a ...[more]

PMID: 31673596

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Dataset Information

Measuring longitudinal cognition: Individual tests versus composites.

Introduction

Methods

Results

Discussion

Publications

Measuring longitudinal cognition: Individual tests versus composites.

Similar Datasets

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