Ontology highlight
ABSTRACT:
SUBMITTER: Hirsch M
PROVIDER: S-EPMC6816549 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Hirsch Michael M Wareham Richard R Yoon Ji W JW Rolfe Daniel J DJ Zanetti-Domingues Laura C LC Hobson Michael P MP Parker Peter J PJ Martin-Fernandez Marisa L ML Singh Sumeetpal S SS
PloS one 20191028 10
The dependence on model-fitting to evaluate particle trajectories makes it difficult for single particle tracking (SPT) to resolve the heterogeneous molecular motions typical of cells. We present here a global spatiotemporal sampler for SPT solutions using a Metropolis-Hastings algorithm. The sampler does not find just the most likely solution but also assesses its likelihood and presents alternative solutions. This enables the estimation of the tracking error. Furthermore the algorithm samples ...[more]