Leucocyte telomere length and paroxysmal atrial fibrillation: A prospective cohort study and systematic review with meta-analysis.

ABSTRACT:

Background

Telomere length is a surrogate marker of biological aging. Whether telomere length predicts the risk of atrial fibrillation (AF) independently of biological aging is controversial. We conducted a cohort study to examine the relationship between telomere length and paroxysmal AF (PAF), followed by a systematic review and meta-analysis of the published literature, incorporating our own data.

Methods

DNA was extracted from peripheral blood. Leucocyte telomere length was measured by a real-time polymerase chain reaction-based method, normalized to a single copy gene, and presented as telomere/single gene ratio (t/s).

Results

A total of 100 non-AF patients and 50 PAF patients (mean age: 61.0 ± 9.4 and 64.0 ± 10.7 years, respectively) were included. T/s for subje

SUBMITTER: Zhang N 

PROVIDER: S-EPMC6816961 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature