A genetic variant in CDKN2A/B gene is associated with the increased risk of breast cancer.

ABSTRACT: Breast cancer is among the leading cause of cancer-related-deaths in women, supporting the need for the identification of novel prognostic and predictive biomarkers. Recent studies have identified common genetic variants in a region on chromosome 9p21 associated with an increased risk of developing different cancers. Here, we explored the association of a genetic variant in CDKN2A/B, rs10811661, for the first time in 564 subjects with/without breast cancer. Genotyping was performed using TaqMan real time PCR method. The associations of this genetic variant with breast cancer risk and pathological information of patients were assessed. We observed that patients with breast cancer had a higher frequency of TT genotype (P<.001) than control group, which was associated with advanced TNM classi

SUBMITTER: ShahidSales S 

PROVIDER: S-EPMC6817096 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature