Polymorphisms of CYP27B1 are associated with IFN efficacy in HBeAg-positive patients.

ABSTRACT:

Background

Host single nucleotide polymorphisms were associated with antiviral therapy in CHB patients. The CYP27B1 gene, encoding 25(OH)D₃ -1α hydroxylase, might activate 25(OH)D₃ to 1,25(OH)₂ D₃ in kidney resulted in influencing the efficacy of interferon (IFN). The aim of the study was to investigate the association between CYP27B1 polymorphisms and the response to IFN in HBeAg-positive patients.

Methods

Eighty-seven HBeAg-positive CHB patients infected with HBV genotype B or C were included in the study. All patients were treated with IFN at least 1 year. According to the response to PEG-IFN therapy, they were divided into three groups: 16 complete responses (CR), 42 partial responses (PR), and 29 nonresponses (NR). Sanger-sequ

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6817160 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature