Unknown

Dataset Information

0

Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations.


ABSTRACT: OBJECTIVES:Posttransplantation diabetes mellitus (PTDM) is a major complication after solid organ transplantation. This study is to investigate the association of nine genetic variant factors and PTDM in Chinese Han patients. METHODS:HLA-DP (rs3077, rs9277535), HLA-DQ (rs7453920), signal transducer and activator of transcription 4 (STAT4) (rs7574865), IL-28B (rs12979860, rs8099917, and rs12980275), and IL-18 (rs1946518 and rs187238) were investigated in 260 liver transplant recipients (PTDM vs non-PTDM) by high-resolution melting curve analysis. Serum interleukin (IL)-1?, IL-6, IL-8, IL-17, interferon-?, inducible protein-10, monocyte chemoattractant protein-1, and macrophage inflammatory protein-1b were analyzed by a Bio-Plex suspension array system (Bio-Plex Multiplex Immunoassays, Bio-Rad, Hercules, CA, USA). RESULTS:Signal transducer and activator of transcription 4 (rs7574865) T allele and IL-18 (rs1946518) A allele increase the risk for insulin resistance and PTDM. CONCLUSIONS:Recipients with STAT4 (rs7574865) T allele are associated with an increased concentration of IL-1?, interferon-?, monocyte chemoattractant protein, and macrophage inflammatory protein-1b. The genetic variants of STAT4 (rs7574865) and IL-18 (rs1946518) may be new important markers for PTDM.

SUBMITTER: Chen J 

PROVIDER: S-EPMC6817172 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations.

Chen Jie J   Li Lixin L   An Yunfei Y   Zhang Junlong J   Liao Yun Y   Li Yi Y   Wang Lanlan L  

Journal of clinical laboratory analysis 20170823 3


<h4>Objectives</h4>Posttransplantation diabetes mellitus (PTDM) is a major complication after solid organ transplantation. This study is to investigate the association of nine genetic variant factors and PTDM in Chinese Han patients.<h4>Methods</h4>HLA-DP (rs3077, rs9277535), HLA-DQ (rs7453920), signal transducer and activator of transcription 4 (STAT4) (rs7574865), IL-28B (rs12979860, rs8099917, and rs12980275), and IL-18 (rs1946518 and rs187238) were investigated in 260 liver transplant recipi  ...[more]

Similar Datasets

| S-EPMC5584624 | biostudies-literature
| S-EPMC3855940 | biostudies-literature
| S-EPMC7325035 | biostudies-literature
| S-EPMC3487121 | biostudies-literature
| S-EPMC4999842 | biostudies-literature
| S-EPMC4583948 | biostudies-literature
| S-EPMC8543917 | biostudies-literature
| S-EPMC4684198 | biostudies-literature
| S-EPMC4121223 | biostudies-literature
| S-EPMC4964615 | biostudies-literature