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The correlation between LIN28B gene potentially functional variants and Wilms tumor susceptibility in Chinese children.


ABSTRACT: BACKGROUND:Wilms tumor (WT) is the most common urologic cancer in children. However, genetic bases underlying WT remain largely unknown. Previous studies indicated that Lin28 homolog B (LIN28B) level is significantly elevated in some WTs. Enforced expression of Lin28b during kidney development could induce WT. Genetic variations in the LIN28B gene may be related to WT susceptibility. METHOD:In this study, we aimed to assess the association between LIN28B gene polymorphisms and WT susceptibility in Chinese children. Four potentially functional polymorphisms in the LIN28B gene (rs314276 C>A, rs221634 A>T, rs221635 T>C and rs9404590 T>G) were genotyped in 145 cases and 531 cancer-free controls, using Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. RESULTS:Our results showed that the rs314276 CA genotype was associated with a decreased WT risk (CA vs CC: adjusted OR=0.65, 95% CI=0.43-0.98, P=.042). Moreover, we found that carriers of the 1-3 risk genotypes had a significantly increased WT risk when compared to the non-carriers (adjusted OR=1.51, 95% CI=1.03-2.20, P=.035). The association with risk genotypes was more predominant in children 18 month old or younger and in females. CONCLUSION:In summary, these results indicated that the LIN28B gene rs314276 C>A polymorphism alone and three combined polymorphisms may be able to modify WT susceptibility in Southern Chinese children. Our findings call for further validation in large studies with different ethnicities involved.

SUBMITTER: Fu W 

PROVIDER: S-EPMC6817198 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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The correlation between LIN28B gene potentially functional variants and Wilms tumor susceptibility in Chinese children.

Fu Wen W   Liu Guo-Chang GC   Zhao Zhang Z   Zhu Jinhong J   Jia Wei W   Zhu Shi-Bo SB   Hu Jin-Hua JH   Wang Feng-Hua FH   He Jing J   Xia Huimin H  

Journal of clinical laboratory analysis 20170316 1


<h4>Background</h4>Wilms tumor (WT) is the most common urologic cancer in children. However, genetic bases underlying WT remain largely unknown. Previous studies indicated that Lin28 homolog B (LIN28B) level is significantly elevated in some WTs. Enforced expression of Lin28b during kidney development could induce WT. Genetic variations in the LIN28B gene may be related to WT susceptibility.<h4>Method</h4>In this study, we aimed to assess the association between LIN28B gene polymorphisms and WT  ...[more]

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