Extended Prophylaxis With Nevirapine Does Not Affect Growth in HIV-Exposed Infants.

ABSTRACT:

Background

Effects of prolonged nevirapine prophylaxis exposure on growth among HIV-exposed uninfected (HEU) infants are unknown. This study examines the impact of extended nevirapine prophylaxis from 6 weeks to 6 months on the growth of HEU infants followed for 18 months and also identifies correlates of incident wasting, stunting, underweight, and low head circumference in the HPTN 046 trial.

Methods

Intention-to-treat analysis examined the effect of extended nevirapine exposure on: weight-for-age Z-score, length-for-age Z-score, weight-for-length Z-score, and head circumference-for-age Z-score. Multivariable linear mixed-effects and Cox proportional hazard models were used to compare growth outcomes between the study arms and identify correlates of incident adverse growth

SUBMITTER: Onyango-Makumbi C 

PROVIDER: S-EPMC6817404 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature