Ontology highlight
ABSTRACT:
SUBMITTER: Wei L
PROVIDER: S-EPMC6817725 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Wei Lifan L Qiao Haoxian H Sit Brandon B Yin Kaiyu K Yang Guanhua G Ma Ruiqing R Ma Jiabao J Yang Chun C Yao Jun J Ma Yue Y Xiao Jingfan J Liu Xiaohong X Zhang Yuanxing Y Waldor Matthew K MK Wang Qiyao Q
iScience 20190925
Bacterial pathogens are thought to activate expression of virulence genes upon detection of host-associated cues, but identification of the nature of such signals has proved difficult. We generated a genome-scale defined transposon mutant library in Edwardsiella piscicida, an important fish pathogen, to quantify the fitness of insertion mutants for intracellular growth in macrophages and in turbot (Scophthalmus maximus). These screens identified EvrA, a transcription activator that induces expre ...[more]