Grandmothers' smoking in pregnancy is associated with a reduced prevalence of early-onset myopia.
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ABSTRACT:
SUBMITTER: Williams C
PROVIDER: S-EPMC6817861 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Grandmothers' smoking in pregnancy is associated with a reduced prevalence of early-onset myopia.
Williams Cathy C Suderman Matthew M Guggenheim Jeremy A JA Ellis Genette G Gregory Steve S Iles-Caven Yasmin Y Northstone Kate K Golding Jean J Pembrey Marcus M
Scientific reports 20191028 1
Myopia (near sightedness) is the most common vision disorder resulting in visual impairment worldwide. We tested the hypothesis that intergenerational, non-genetic heritable effects influence refractive development, using grandparental prenatal smoking as a candidate exposure. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), we found that the prevalence of myopia at age 7 was lower if the paternal grandmother had smoked in pregnancy, an association primarily found am ...[more]
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