Ontology highlight
ABSTRACT:
SUBMITTER: Ge X
PROVIDER: S-EPMC6817905 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Scientific reports 20191028 1
The bacterial ribosome is an important drug target for antibiotics that can inhibit different stages of protein synthesis. Among the various classes of compounds that impair translation there are, however, no known small-molecule inhibitors that specifically target ribosomal release factors (RFs). The class I RFs are essential for correct termination of translation and they differ considerably between bacteria and eukaryotes, making them potential targets for inhibiting bacterial protein synthes ...[more]