Unknown

Dataset Information

0

CYP2C9*2 is associated with indomethacin treatment failure for patent ductus arteriosus.


ABSTRACT: Aims: To identify clinical andgenetic factors associated with indomethacin treatment failure in preterm neonates with patent ductus arteriosus (PDA). Patients & Methods: This is a multicenter cohort study of 144 preterm infants (22-32 weeks gestational age) at three centers who received at least one treatment course of indomethacin for PDA. Indomethacin failure was defined as requiring subsequent surgical intervention. Results: In multivariate analysis, gestational age (AOR 0.76, 95% CI 0.60-0.96), surfactant use (AOR 9.77, 95% CI 1.15-83.26), and CYP2C9*2 (AOR 3.74; 95% CI 1.34-10.44) were each associated with indomethacin failure. Conclusion: Age, surfactant use, and CYP2C9*2 influence indomethacin treatment outcome in preterm infants with PDA. This combination of clinical and genetic factors may facilitate targeted indomethacin use for PDA.

SUBMITTER: Rooney SR 

PROVIDER: S-EPMC6817966 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

<i>CYP2C9*2</i> is associated with indomethacin treatment failure for patent ductus arteriosus.

Rooney Sydney R SR   Shelton Elaine L EL   Aka Ida I   Shaffer Christian M CM   Clyman Ronald I RI   Dagle John M JM   Ryckman Kelli K   Lewis Tamorah R TR   Reese Jeff J   Van Driest Sara L SL   Kannankeril Prince J PJ  

Pharmacogenomics 20190801 13


<b>Aims:</b> To identify clinical andgenetic factors associated with indomethacin treatment failure in preterm neonates with patent ductus arteriosus (PDA). <b>Patients & Methods:</b> This is a multicenter cohort study of 144 preterm infants (22-32 weeks gestational age) at three centers who received at least one treatment course of indomethacin for PDA. Indomethacin failure was defined as requiring subsequent surgical intervention. <b>Results:</b> In multivariate analysis, gestational age (AOR  ...[more]

Similar Datasets

| S-EPMC5645220 | biostudies-literature
| S-EPMC3683087 | biostudies-literature
| S-EPMC8095061 | biostudies-literature
| S-EPMC5554551 | biostudies-other
| S-EPMC8575391 | biostudies-literature
| S-EPMC8617388 | biostudies-literature
| S-EPMC6237953 | biostudies-literature
| S-EPMC7605084 | biostudies-literature
| S-EPMC6391165 | biostudies-literature
| S-EPMC4935651 | biostudies-literature