Ontology highlight
ABSTRACT:
SUBMITTER: Rooney SR
PROVIDER: S-EPMC6817966 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Rooney Sydney R SR Shelton Elaine L EL Aka Ida I Shaffer Christian M CM Clyman Ronald I RI Dagle John M JM Ryckman Kelli K Lewis Tamorah R TR Reese Jeff J Van Driest Sara L SL Kannankeril Prince J PJ
Pharmacogenomics 20190801 13
<b>Aims:</b> To identify clinical andgenetic factors associated with indomethacin treatment failure in preterm neonates with patent ductus arteriosus (PDA). <b>Patients & Methods:</b> This is a multicenter cohort study of 144 preterm infants (22-32 weeks gestational age) at three centers who received at least one treatment course of indomethacin for PDA. Indomethacin failure was defined as requiring subsequent surgical intervention. <b>Results:</b> In multivariate analysis, gestational age (AOR ...[more]