Effects of Simvastatin on Augmentation Index Are Transient: Outcomes From a Randomized Controlled Trial.

ABSTRACT: Background Statins improve endothelial function, but their effects on arterial stiffness and aortic blood pressure in middle-aged adults are uncertain. Methods and Results This was a prospective, randomized, double-blind, placebo-controlled trial of middle-aged (40-72 years old) adults who were randomly assigned to receive simvastatin 40 mg (n=44) or placebo (n=44) daily for 18 months to evaluate impact on dementia-related biomarkers (primary end points) and measures of vascular health (secondary end points). This analysis focuses on the predetermined secondary end points of changes in central aortic blood pressure, aortic augmentation index, and brachial artery flow-mediated dilation. Measurements were performed at baseline and after 6, 12, and 18 months. Multivariable models were used to

SUBMITTER: Gepner AD 

PROVIDER: S-EPMC6818042 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature