Ontology highlight
ABSTRACT:
SUBMITTER: Zhang D
PROVIDER: S-EPMC6818755 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhang Di D Tang Zhanyun Z Huang He H Zhou Guolin G Cui Chang C Weng Yejing Y Liu Wenchao W Kim Sunjoo S Lee Sangkyu S Perez-Neut Mathew M Ding Jun J Czyz Daniel D Hu Rong R Ye Zhen Z He Maomao M Zheng Y George YG Shuman Howard A HA Dai Lunzhi L Ren Bing B Roeder Robert G RG Becker Lev L Zhao Yingming Y
Nature 20191023 7779
The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells. This phenomenon is intimately linked to several diseases including neoplasia, sepsis and autoimmune diseases<sup>1,2</sup>. Lactate, which is converted from pyruvate in tumour cells, is widely known as an energy source and metabolic by-product. However, its non-metabolic functi ...[more]