Browse
Submit Data
Databases
API
Help

Dataset Information

18 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tailor-Made Engineering of Bioinspired Inks for Writing Barcode-like Multifunctional Sensory Electronics.

ABSTRACT: This letter reports on a novel cost-efficient and multifunctional barcode-like sensors array (BLSA) printed with a conductive bioinspired smart ink. The conductive ink (P@G ink), which can be further chemically engineered with different organic ligands, was generated via facile one-pot hydrothermal reduction of graphene oxide (GO) in dopamine (DA) as coreductan Usingvarious chemical derivatives of the P@G inks on a flexible substrate (e.g., Kapton), a highly integrated BLSA as well as smart nose/tongue mimic array were generated for simultaneous sensing and distinguishing of complex physical and chemical stimuli, including temperature, light, air pressure, relative humidity, and volatile organic compounds (VOCs). Due to these very attractive features, the reported P@G ink-based BLSA would have the potential for unique opportunities regarding "all-in-one"-yet cost-effective-disposable electronics and sensors.

SUBMITTER: Zhang M

PROVIDER: S-EPMC6819985 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Silicate-Based Electro-Conductive Inks for Printing Soft Electronics and Tissue Engineering.

Project description:Hydrogel-based bio-inks have been extensively used for developing three-dimensional (3D) printed biomaterials for biomedical applications. However, poor mechanical performance and the inability to conduct electricity limit their application as wearable sensors. In this work, we formulate a novel, 3D printable electro-conductive hydrogel consisting of silicate nanosheets (Laponite), graphene oxide, and alginate. The result generated a stretchable, soft, but durable electro-conductive material suitable for utilization as a novel electro-conductive bio-ink for the extrusion printing of different biomedical platforms, including flexible electronics, tissue engineering, and drug delivery. A series of tensile tests were performed on the material, indicating excellent stability under significant stretching and bending without any conductive or mechanical failures. Rheological characterization revealed that the addition of Laponite enhanced the hydrogel's mechanical properties, including stiffness, shear-thinning, and stretchability. We also illustrate the reproducibility and flexibility of our fabrication process by extrusion printing various patterns with different fiber diameters. Developing an electro-conductive bio-ink with favorable mechanical and electrical properties offers a new platform for advanced tissue engineering.

| S-EPMC8702023 | biostudies-literature

Engineering <i>Ustilago maydis</i> for production of tailor-made mannosylerythritol lipids.

Project description:Mannosylerythritol lipids (MELs) are surface active glycolipids secreted by various fungi. MELs can be used as biosurfactants and are a biodegradable resource for the production of detergents or pharmaceuticals. Different fungal species synthesize a unique mixture of MELs differing in acetyl- and acyl-groups attached to the sugar moiety. Here, we report the construction of a toolbox for production of glycolipids with predictable fatty acid side chains in the basidiomycete Ustilago maydis. Genes coding for acyl-transferases involved in MEL production (Mac1 and Mac2) from different fungal species were combined to obtain altered MEL variants with distinct physical properties and altered antimicrobial activity. We also demonstrate that a U. maydis paralog of the acyltransferase Mac2 with a different substrate specificity can be employed for the biosynthesis of modified MEL variants. In summary, our data showcase how the fungal repertoire of Mac enzymes can be used to engineer tailor-made MELs according to specific biotechnological or pharmaceutical requirements.

| S-EPMC7896148 | biostudies-literature

Bioinspired neuron-like electronics.

Project description:As an important application of functional biomaterials, neural probes have contributed substantially to studying the brain. Bioinspired and biomimetic strategies have begun to be applied to the development of neural probes, although these and previous generations of probes have had structural and mechanical dissimilarities from their neuron targets that lead to neuronal loss, neuroinflammatory responses and measurement instabilities. Here, we present a bioinspired design for neural probes-neuron-like electronics (NeuE)-where the key building blocks mimic the subcellular structural features and mechanical properties of neurons. Full three-dimensional mapping of implanted NeuE-brain interfaces highlights the structural indistinguishability and intimate interpenetration of NeuE and neurons. Time-dependent histology and electrophysiology studies further reveal a structurally and functionally stable interface with the neuronal and glial networks shortly following implantation, thus opening opportunities for next-generation brain-machine interfaces. Finally, the NeuE subcellular structural features are shown to facilitate migration of endogenous neural progenitor cells, thus holding promise as an electrically active platform for transplantation-free regenerative medicine.

| S-EPMC6474791 | biostudies-literature

Site-Selective Acylations with Tailor-Made Catalysts.

Project description:The acylation of alcohols catalyzed by N,N-dimethylamino pyridine (DMAP) is, despite its widespread use, sometimes confronted with substrate-specific problems: For example, target compounds with multiple hydroxy groups may show insufficient selectivity for one hydroxyl, and the resulting product mixtures are hardly separable. Here we describe a concept that aims at tailor-made catalysts for the site-specific acylation. To this end, we introduce a catalyst library where each entry is constructed by connecting a variable and readily tuned peptide scaffold with a catalytically active unit based on DMAP. For selected examples, we demonstrate how library screening leads to the identification of optimized catalysts, and the substrates of interest can be converted with a markedly enhanced site-selectivity compared with only DMAP. Furthermore, substrate-optimized catalysts of this type can be used to selectively convert "their" substrate in the presence of structurally similar compounds, an important requisite for reactions with mixtures of substances.

| S-EPMC5069569 | biostudies-literature

Surface-Modified Substrates for Quantum Dot Inks in Printed Electronics.

Project description:Printed electronics fill the niches for low-cost, flexible devices in electronics. Developing substrates suitable for various printable electronic inks becomes an important topic in both academia and industry. Because of their extraordinary properties like solution processability, colloidal quantum dots (QDs) are gradually emerging in this field as promising candidates for electronic inks. In recent years, researchers have successfully produced high quality PbS QD inks in polar solvents. However, the incorporation of electronic inks onto a well-passivated substrate remains challenging due to the processing incompatibility between polar solvents and hydrophobic substrates. Here, we propose a surface modification strategy by using chlorine to achieve both trap-site suppression and a hydrophilic surface. The chlorine can effectively passivate the surface dangling bonds and charged hydroxyls while creating a hydrophilic surface. On this modified substrate, the contact angle between the water droplet and the SiO2 substrate can be as small as 20° and this strategy is also feasible for other polymer and inorganic substrates. For a proof-of-concept demonstration, we fabricated a PbS QD ink-based field-effect transistor on a Cl-passivated substrate, and the device showed a mobility as high as 4.36 × 10-3 cm2/V s, which indicates effective trap-site suppression. This device also enables the potential of the Cl-passivated substrates for QD inks with water or other polar solvents.

| S-EPMC6648829 | biostudies-literature

Zinc Finger Nucleases: Tailor-made for Gene Therapy.

Project description:Genome editing with the use of zinc finger nucleases has been successfully applied to variety of a eukaryotic cells. Furthermore, the proof of concept for this approach has been extended to diverse animal models from Drosophila to mice. Engineered zinc finger nucleases are able to target specifically and manipulate disease-causing genes through site-specific double strand DNA breaks followed by non-homologous end joining or homologous recombination mechanisms. Consequently, this technology has considerable flexibility that can result in either a gain or loss of function of the targeted gene. In addition to this flexibility, gene therapy by zinc finger nucleases may enable persistent long term gene modification without continuous transfection- a potential advantage over RNA interference or direct gene inhibitors. With systemic viral delivery systems, this gene-editing approach corrected the mutant factor IX in models of mouse hemophilia. Moreover, phase I clinical trials have been initiated with zinc finger nucleases in patients with glioblastoma and HIV. Thus, this emerging field has significant promise as a therapeutic strategy for human genetic diseases, infectious diseases and oncology. In this article, we will review recent advances and potential risks in zinc finger nuclease gene therapy.

| S-EPMC3801298 | biostudies-literature

Direct writing of customized structural-color graphics with colloidal photonic inks.

Project description:[Figure: see text].

| S-EPMC8612532 | biostudies-literature

Programmable Porous Polymers via Direct Bubble Writing with Surfactant-Free Inks.

Project description:Fabrication of macroporous polymers with functionally graded architecture or chemistry bears transformative potential in acoustic damping, energy storage materials, flexible electronics, and filtration but is hardly reachable with current processes. Here, we introduce thiol-ene chemistries in direct bubble writing, a recent technique for additive manufacturing of foams with locally controlled cell size, density, and macroscopic shape. Surfactant-free and solvent-free graded three-dimensional (3D) foams without drying-induced shrinkage were fabricated by direct bubble writing at an unparalleled ink viscosity of 410 cP (40 times higher than previous formulations). Functionalities including shape memory, high glass transition temperatures (>25 °C), and chemical gradients were demonstrated. These results extend direct bubble writing from aqueous inks to nonaqueous formulations at high liquid flow rates (3 mL min-1). Altogether, direct bubble writing with thiol-ene inks promises rapid one-step fabrication of functional materials with locally controlled gradients in the chemical, mechanical, and architectural domains.

| S-EPMC7503514 | biostudies-literature

Tailor-made temperature-dependent thermal conductivity via interparticle constriction.

Project description:Managing heat is a major challenge to meet future demands for a sustainable use of our energy resources. This requires materials, which can be custom-designed to exhibit specific temperature-dependent thermal transport properties to become integrated into thermal switches, transistors, or diodes. Common crystalline and amorphous materials are not suitable, owing to their gradual changes of the temperature-dependent thermal conductivity. We show how a second-order phase transition fully controls the temperature-dependent thermal transport properties of polymer materials. We demonstrate four major concepts based on a colloidal superstructure: (i) control of transition temperature, (ii) width of phase transition regime, (iii) multistep transitions, and (iv) step height of the transition. Most importantly, this unique control over thermal conductivity is only governed by the interparticle constriction, the particle composition, and its mesostructure. Our concept is therefore also applicable to a wide variety of other particulate materials.

| S-EPMC5693563 | biostudies-literature

Molecular Scissors for Tailor-Made Modification of Siloxane Scaffolds.

Project description:The controlled design of functional oligosiloxanes is an important topic in current research. A consecutive Si-O-Si bond cleavage/formation using siloxanes that are substituted with 1,2-diaminobenzene derivatives acting as molecular scissors is presented. The method allows to cut at certain positions of a siloxane scaffold forming a cyclic diaminosilane or -siloxane intermediate and then to introduce new functional siloxy units. The procedure could be extended to a direct one-step cleavage of chlorooligosiloxanes. Both siloxane formation and cleavage proceed with good to excellent yields, high regioselectivity, and great variability of the siloxy units. Control of the selectivity is achieved by the choice of the amino substituent. Insight into the mechanism was provided by low temperature NMR studies and the isolation of a lithiated intermediate.

| S-EPMC9299477 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data