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Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis.

ABSTRACT: Importance:Biphasic anaphylaxis may occur in up to 20% of patients with anaphylaxis; however, the optimal observation time of patients with resolved anaphylaxis is unknown. Objective:To characterize the cost-effectiveness of short vs prolonged medical observation times after resolved anaphylaxis. Design, Setting, and Participants:An economic evaluation was performed of computer-simulated adult patients observed in outpatient allergy clinics and emergency departments, with rates of biphasic anaphylaxis derived from a 2019 meta-analysis. Exposures:Computer-simulated patients (10?000 per strategy) were randomized to undergo 1 hour of medical observation (associated with 95% negative predictive value of biphasic anaphylaxis) or 6 or more hours of observation (associated with a 97.3% negative predictive value of biphasic anaphylaxis). Main Outcomes and Measures:Cost-effectiveness of 6- to 24-hour medical observation of resolved anaphylaxis evaluated at willingness-to-pay thresholds of $10?000 per case of biphasic anaphylaxis observed and $10 million per death prevented, assuming that observation is associated with a 10- to 1000-fold reduction in the risk of death due to biphasic anaphylaxis. Results:Biphasic anaphylaxis occurred after hospital discharge in 365 patients observed for 1 hour and in 213 patients undergoing prolonged observation. From a health care sector perspective, with medical observation costs of $286.92 per hour, the incremental cost of extended medical observation of resolved anaphylaxis (1 hour vs 6 hours) was $62?374 per case of biphasic anaphylaxis identified ($68?411 from the societal perspective). In Monte Carlo simulations, with hourly costs ranging from $100 to $500 and extended observation ranging from 6 to 24 hours (health care sector perspective), the mean (SD) costs were $295.36 ($81.22) for 1 hour of observation vs $3540.42 ($1626.67) for extended observation. The incremental cost-effectiveness ratio was $213?439 per biphasic anaphylaxis observed ($230?202 from the societal perspective). A 6-hour observation could be cost-effective if the risk of biphasic anaphylaxis after 1-hour observation of resolved anaphylaxis was 17% or if hourly observation costs were less than $46 in the base case. Cost-effectiveness could also be achieved (willingness-to-pay of $10?million per death prevented, health care sector perspective) when a baseline fatality rate of 0.33% per biphasic anaphylactic event was assumed, with a no greater than 24% relative risk of fatality associated with 6-hour observation. Conclusions and Relevance:This study indicates that prolonged medical observation (6-24 hours) for resolved anaphylaxis may not be cost-effective for patients at low risk for biphasic anaphylaxis; however, in particular clinical circumstances of low observation costs, high postdischarge risk of biphasic anaphylaxis, or large incremental fatality risk reduction associated with extended observation, longer medical observation can be justified.

SUBMITTER: Shaker M

PROVIDER: S-EPMC6820064 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis.

Shaker Marcus M Wallace Dana D Golden David B K DBK Oppenheimer John J Greenhawt Matthew M

JAMA network open 20191002 10

<h4>Importance</h4>Biphasic anaphylaxis may occur in up to 20% of patients with anaphylaxis; however, the optimal observation time of patients with resolved anaphylaxis is unknown.<h4>Objective</h4>To characterize the cost-effectiveness of short vs prolonged medical observation times after resolved anaphylaxis.<h4>Design, setting, and participants</h4>An economic evaluation was performed of computer-simulated adult patients observed in outpatient allergy clinics and emergency departments, with r ...[more]

PMID: 31642933

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Dataset Information

Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis.

Publications

Simulation of Health and Economic Benefits of Extended Observation of Resolved Anaphylaxis.

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