Ontology highlight
ABSTRACT:
SUBMITTER: Wee CL
PROVIDER: S-EPMC6820349 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wee Caroline L CL Nikitchenko Maxim M Wang Wei-Chun WC Luks-Morgan Sasha J SJ Song Erin E Gagnon James A JA Randlett Owen O Bianco Isaac H IH Lacoste Alix M B AMB Glushenkova Elena E Barrios Joshua P JP Schier Alexander F AF Kunes Samuel S Engert Florian F Douglass Adam D AD
Nature neuroscience 20190729 9
Animals have evolved specialized neural circuits to defend themselves from pain- and injury-causing stimuli. Using a combination of optical, behavioral and genetic approaches in the larval zebrafish, we describe a novel role for hypothalamic oxytocin (OXT) neurons in the processing of noxious stimuli. In vivo imaging revealed that a large and distributed fraction of zebrafish OXT neurons respond strongly to noxious inputs, including the activation of damage-sensing TRPA1 receptors. OXT populatio ...[more]