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Genetics of perioperative pain management.


ABSTRACT: PURPOSE OF REVIEW:The current review will discuss the current literature on genetics of pain and analgesia, with special emphasis on perioperative setting. We will also discuss pharmacogenetics-based management guidelines, current clinical status and future perspectives. RECENT FINDINGS:Recent literature suggests that the interindividual variability in pain and postoperative analgesic response is at least in part because of one's genetic make-up. Some of the well characterized polymorphisms that are associated with surgical pain and opioid-related postoperative adverse outcomes are described in catechol-O-methyl transferase, CYP2D6 and ?-opioid receptor (OPRM1), ATP-binding cassette subfamily B member 1, ABCC3, organic cation transporter 1 genes. Clinical Pharmacogenetics Implementation Consortium has put forth recommendations on CYP2D6 genotype-based opioid selection and dosing. The list of drug-gene pairs studied continue to expand. SUMMARY:Pharmacogenetic approach marks the dawn of personalized pain medicine both in perioperative and chronic pain settings.

SUBMITTER: Packiasabapathy S 

PROVIDER: S-EPMC6820692 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Genetics of perioperative pain management.

Packiasabapathy Senthil S   Horn Nicole N   Sadhasivam Senthilkumar S  

Current opinion in anaesthesiology 20181201 6


<h4>Purpose of review</h4>The current review will discuss the current literature on genetics of pain and analgesia, with special emphasis on perioperative setting. We will also discuss pharmacogenetics-based management guidelines, current clinical status and future perspectives.<h4>Recent findings</h4>Recent literature suggests that the interindividual variability in pain and postoperative analgesic response is at least in part because of one's genetic make-up. Some of the well characterized pol  ...[more]

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