Ontology highlight
ABSTRACT:
SUBMITTER: Li YJ
PROVIDER: S-EPMC6820788 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Li Yu-Jie YJ Cao Yu-Lu YL Feng Jian-Xiong JX Qi Yuanbo Y Meng Shuxia S Yang Jie-Feng JF Zhong Ya-Ting YT Kang Sisi S Chen Xiaoxue X Lan Lan L Luo Li L Yu Bing B Chen Shoudeng S Chan David C DC Hu Junjie J Gao Song S
Nature communications 20191029 1
Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays a central role in regulating mitochondrial fusion and cell metabolism. Mutations in MFN2 cause the neurodegenerative disease Charcot-Marie-Tooth type 2A (CMT2A). The molecular basis underlying the physiological and pathological relevance of MFN2 is unclear. Here, we present crystal structures of truncated human MFN2 in different nucleotide-loading states. Unlike other dynamin superfamily members including MFN1, MFN2 forms sustained dimers ev ...[more]