Ontology highlight
ABSTRACT:
SUBMITTER: Seffouh A
PROVIDER: S-EPMC6821245 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Seffouh Amal A Jain Nikhil N Jahagirdar Dushyant D Basu Kaustuv K Razi Aida A Ni Xiaodan X Guarné Alba A Britton Robert A RA Ortega Joaquin J
Nucleic acids research 20191101 19
Bacteria harbor a number GTPases that function in the assembly of the ribosome and are essential for growth. RbgA is one of these GTPases and is required for the assembly of the 50S subunit in most bacteria. Homologs of this protein are also implicated in the assembly of the large subunit of the mitochondrial and eukaryotic ribosome. We present here the cryo-electron microscopy structure of RbgA bound to a Bacillus subtilis 50S subunit assembly intermediate (45SRbgA particle) that accumulates in ...[more]