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SimuG: a general-purpose genome simulator.

ABSTRACT: SUMMARY:Simulated genomes with pre-defined and random genomic variants can be very useful for benchmarking genomic and bioinformatics analyses. Here we introduce simuG, a lightweight tool for simulating the full-spectrum of genomic variants (single nucleotide polymorphisms, Insertions/Deletions, copy number variants, inversions and translocations) for any organisms (including human). The simplicity and versatility of simuG make it a unique general-purpose genome simulator for a wide-range of simulation-based applications. AVAILABILITY AND IMPLEMENTATION:Code in Perl along with user manual and testing data is available at https://github.com/yjx1217/simuG. This software is free for use under the MIT license. SUPPLEMENTARY INFORMATION:Supplementary data are available at Bioinformatics online.

SUBMITTER: Yue JX

PROVIDER: S-EPMC6821417 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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simuG: a general-purpose genome simulator.

Yue Jia-Xing JX Liti Gianni G

Bioinformatics (Oxford, England) 20191101 21

<h4>Summary</h4>Simulated genomes with pre-defined and random genomic variants can be very useful for benchmarking genomic and bioinformatics analyses. Here we introduce simuG, a lightweight tool for simulating the full-spectrum of genomic variants (single nucleotide polymorphisms, Insertions/Deletions, copy number variants, inversions and translocations) for any organisms (including human). The simplicity and versatility of simuG make it a unique general-purpose genome simulator for a wide-rang ...[more]

PMID: 31116378

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