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ABSTRACT:
SUBMITTER: Sgouralis I
PROVIDER: S-EPMC6821439 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Sgouralis Ioannis I Madaan Shreya S Djutanta Franky F Kha Rachael R Hariadi Rizal F RF Pressé Steve S
The journal of physical chemistry. B 20190110 3
We develop a Bayesian nonparametric framework to analyze single molecule FRET (smFRET) data. This framework, a variation on infinite hidden Markov models, goes beyond traditional hidden Markov analysis, which already treats photon shot noise, in three critical ways: (1) it learns the number of molecular states present in a smFRET time trace (a hallmark of nonparametric approaches), (2) it accounts, simultaneously and self-consistently, for photophysical features of donor and acceptor fluorophore ...[more]