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Unlocking the molecular secrets of sodium-coupled transporters.

ABSTRACT: Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation between functionally unrelated transporters. These atomic-resolution structures are revealing the mechanism of the sodium-coupled transport of solutes across cellular membranes.

SUBMITTER: Krishnamurthy H

PROVIDER: S-EPMC6821466 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Unlocking the molecular secrets of sodium-coupled transporters.

Krishnamurthy Harini H Piscitelli Chayne L CL Gouaux Eric E

Nature 20090501 7245

Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation ...[more]

PMID: 19458710

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