Unlocking the molecular secrets of sodium-coupled transporters.
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ABSTRACT:
SUBMITTER: Krishnamurthy H
PROVIDER: S-EPMC6821466 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Publications
Unlocking the molecular secrets of sodium-coupled transporters.
Krishnamurthy Harini H Piscitelli Chayne L CL Gouaux Eric E
Nature 20090501 7245
Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell. Decades of study have shown that such sodium-coupled transporters are involved in many physiological processes, making them targets for the treatment of numerous diseases. Within the past year, crystal structures of several sodium-coupled transporters from different families have been reported, showing a remarkable structural conservation ...[more]
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