Ontology highlight
ABSTRACT:
SUBMITTER: Di Iorio BR
PROVIDER: S-EPMC6821658 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Di Iorio Biagio R BR Bellasi Antonio A Raphael Kalani L KL Santoro Domenico D Aucella Filippo F Garofano Luciano L Ceccarelli Michele M Di Lullo Luca L Capolongo Giovanna G Di Iorio Mattia M Guastaferro Pasquale P Capasso Giovambattista G
Journal of nephrology 20191009 6
<h4>Background</h4>Metabolic acidosis is associated with accelerated progression of chronic kidney disease (CKD). Whether treatment of metabolic acidosis with sodium bicarbonate improves kidney and patient survival in CKD is unclear.<h4>Methods</h4>We conducted a randomized (ratio 1:1). open-label, controlled trial (NCT number: NCT01640119. www.clinicaltrials.gov ) to determine the effect in patients with CKD stage 3-5 of treatment of metabolic acidosis with sodium bicarbonate (SB) on creatinine ...[more]