Ontology highlight
ABSTRACT:
SUBMITTER: Ladenbauer J
PROVIDER: S-EPMC6821748 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Ladenbauer Josef J McKenzie Sam S English Daniel Fine DF Hagens Olivier O Ostojic Srdjan S
Nature communications 20191030 1
The interpretation of neuronal spike train recordings often relies on abstract statistical models that allow for principled parameter estimation and model selection but provide only limited insights into underlying microcircuits. In contrast, mechanistic models are useful to interpret microcircuit dynamics, but are rarely quantitatively matched to experimental data due to methodological challenges. Here we present analytical methods to efficiently fit spiking circuit models to single-trial spike ...[more]