Ontology highlight
ABSTRACT:
SUBMITTER: Brandt MM
PROVIDER: S-EPMC6821775 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Brandt Maarten M MM van Dijk Christian G M CGM Maringanti Ranganath R Chrifi Ihsan I Kramann Rafael R Verhaar Marianne C MC Duncker Dirk J DJ Mokry Michal M Cheng Caroline C
Scientific reports 20191030 1
Microvascular homeostasis is strictly regulated, requiring close interaction between endothelial cells and pericytes. Here, we aimed to improve our understanding of how microvascular crosstalk affects pericytes. Human-derived pericytes, cultured in absence, or presence of human endothelial cells, were studied by RNA sequencing. Compared with mono-cultured pericytes, a total of 6704 genes were differentially expressed in co-cultured pericytes. Direct endothelial contact induced transcriptome prof ...[more]