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Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes.

ABSTRACT: Rosacea is a common, chronic skin disease of variable severity with limited treatment options. The cause of rosacea is unknown, but it is believed to be due to a combination of hereditary and environmental factors. Little is known about the genetics of the disease. We performed a genome-wide association study (GWAS) of rosacea symptom severity with data from 73?265 research participants of European ancestry from the 23andMe customer base. Seven loci had variants associated with rosacea at the genome-wide significance level (P?

SUBMITTER: Aponte JL

PROVIDER: S-EPMC6822543 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature

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Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes.

Aponte Jennifer L JL Chiano Mathias N MN Yerges-Armstrong Laura M LM Hinds David A DA Tian Chao C Gupta Akanksha A Guo Cong C Fraser Dana J DJ Freudenberg Johannes M JM Rajpal Deepak K DK Ehm Margaret G MG Waterworth Dawn M DM

Human molecular genetics 20180801 15

Rosacea is a common, chronic skin disease of variable severity with limited treatment options. The cause of rosacea is unknown, but it is believed to be due to a combination of hereditary and environmental factors. Little is known about the genetics of the disease. We performed a genome-wide association study (GWAS) of rosacea symptom severity with data from 73 265 research participants of European ancestry from the 23andMe customer base. Seven loci had variants associated with rosacea at the ge ...[more]

PMID: 29771307

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