Ontology highlight
ABSTRACT:
SUBMITTER: Dodean RA
PROVIDER: S-EPMC6822569 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20190321 7
Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-stage activity against both liver-stage and blood-stage malaria. Several lead compounds generated from structural optimization of a large library of novel acridones exhibit efficacy in the following systems: (1) picomolar inhibition of in vitro Plasmod ...[more]