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Traumatic Stress Produces Delayed Alterations of Synaptic Plasticity in Basolateral Amygdala.


ABSTRACT: Acute traumatic event exposure is a direct cause of post-traumatic stress disorder (PTSD). Amygdala is suggested to be associated with the development of PTSD. In our previous findings, different activation patterns of GABAergic neurons and glutamatergic neurons in early or late stages after stress were found. However, the neural plastic mechanism underlying the role of basolateral amygdala (BLA) in post-traumatic stress disorder remains unclear. Therefore, this study mainly aimed at investigating time-dependent morphologic and electrophysiological changes in BLA during the development of PTSD. We used single prolonged stress (SPS) procedure to establish PTSD model of rats. The rats showed no alterations in anxiety behavior as well as in dendritic spine density or synaptic transmission in BLA 1 day after SPS. However, 10 days after SPS, rats showed enhancement of anxiety behavior, and spine density and frequency of miniature excitatory and inhibitory postsynaptic currents in BLA. Our results suggested that after traumatic stress, BLA displayed delayed increase in both spinogenesis and synaptic transmission, which seemed to facilitate the development of PTSD.

SUBMITTER: Zhang HH 

PROVIDER: S-EPMC6824323 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Traumatic Stress Produces Delayed Alterations of Synaptic Plasticity in Basolateral Amygdala.

Zhang Huan-Huan HH   Meng Shi-Qiu SQ   Guo Xin-Yi XY   Zhang Jing-Liang JL   Zhang Wen W   Chen Ya-Yun YY   Lu Lin L   Yang Jian-Li JL   Xue Yan-Xue YX  

Frontiers in psychology 20191025


Acute traumatic event exposure is a direct cause of post-traumatic stress disorder (PTSD). Amygdala is suggested to be associated with the development of PTSD. In our previous findings, different activation patterns of GABAergic neurons and glutamatergic neurons in early or late stages after stress were found. However, the neural plastic mechanism underlying the role of basolateral amygdala (BLA) in post-traumatic stress disorder remains unclear. Therefore, this study mainly aimed at investigati  ...[more]

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