Ontology highlight
ABSTRACT:
SUBMITTER: Gemta LF
PROVIDER: S-EPMC6824424 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Gemta Lelisa F LF Siska Peter J PJ Nelson Marin E ME Gao Xia X Liu Xiaojing X Locasale Jason W JW Yagita Hideo H Slingluff Craig L CL Hoehn Kyle L KL Rathmell Jeffrey C JC Bullock Timothy N J TNJ
Science immunology 20190101 31
In the context of solid tumors, there is a positive correlation between the accumulation of cytotoxic CD8<sup>+</sup> tumor-infiltrating lymphocytes (TILs) and favorable clinical outcomes. However, CD8<sup>+</sup> TILs often exhibit a state of functional exhaustion, limiting their activity, and the underlying molecular basis of this dysfunction is not fully understood. Here, we show that TILs found in human and murine CD8<sup>+</sup> melanomas are metabolically compromised with deficits in both ...[more]