Ontology highlight
ABSTRACT:
SUBMITTER: Patel NJ
PROVIDER: S-EPMC6824442 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Patel Nehal J NJ Nassal Drew M DM Greer-Short Amara D AD Unudurthi Sathya D SD Scandling Benjamin W BW Gratz Daniel D Xu Xianyao X Kalyanasundaram Anuradha A Fedorov Vadim V VV Accornero Federica F Mohler Peter J PJ Gooch Keith J KJ Hund Thomas J TJ
JCI insight 20191017 20
Increased fibrosis is a characteristic remodeling response to biomechanical and neurohumoral stress and a determinant of cardiac mechanical and electrical dysfunction in disease. Stress-induced activation of cardiac fibroblasts (CFs) is a critical step in the fibrotic response, although the precise sequence of events underlying activation of these critical cells in vivo remain unclear. Here, we tested the hypothesis that a βIV-spectrin/STAT3 complex is essential for maintenance of a quiescent ph ...[more]