Ontology highlight
ABSTRACT:
SUBMITTER: Rashkovan M
PROVIDER: S-EPMC6824464 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Rashkovan Marissa M Ferrando Adolfo A
Genes & development 20191101 21-22
Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene addiction with significant implications for the development of targeted therapies. This review explores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumor ...[more]