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Alkyne Hydroheteroarylation: Enantioselective Coupling of Indoles and Alkynes via Rh-Hydride Catalysis.

ABSTRACT: We report an enantioselective coupling between alkynes and indoles. A Rh-hydride catalyst isomerizes alkynes to generate a metal-allyl species that can be trapped with both aromatic and heteroaromatic nucleophiles.

SUBMITTER: Cruz FA

PROVIDER: S-EPMC6824589 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Alkyne Hydroheteroarylation: Enantioselective Coupling of Indoles and Alkynes via Rh-Hydride Catalysis.

Cruz Faben A FA Zhu Yamin Y Tercenio Quentin D QD Shen Zengming Z Dong Vy M VM

Journal of the American Chemical Society 20170725 31

We report an enantioselective coupling between alkynes and indoles. A Rh-hydride catalyst isomerizes alkynes to generate a metal-allyl species that can be trapped with both aromatic and heteroaromatic nucleophiles. ...[more]

PMID: 28742333

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