Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter.
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ABSTRACT:
SUBMITTER: Zhen AX
PROVIDER: S-EPMC6824628 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter.
Zhen Ao Xuan AX Piao Mei Jing MJ Kang Kyoung Ah KA Fernando Pincha Devage Sameera Madushan PDSM Kang Hee Kyoung HK Koh Young Sang YS Yi Joo Mi JM Hyun Jin Won JW
Biomolecules & therapeutics 20191101 6
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that particulate matter 2.5 (PM<sub>2.5</sub>) induced reactive oxygen species (ROS), causing disruption of DNA, lipids, and proteins; mitochondrial depolarization, and apoptosis of skin keratinocytes. Here, we investigated the protective effects of NIA on PM<sub>2.5</sub>-induced oxidative stress in hum ...[more]
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