Cytokine Release Syndrome: Current Perspectives.
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ABSTRACT:
SUBMITTER: Murthy H
PROVIDER: S-EPMC6825470 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Cytokine Release Syndrome: Current Perspectives.
Murthy Hemant H Iqbal Madiha M Chavez Julio C JC Kharfan-Dabaja Mohamed A MA
ImmunoTargets and therapy 20191029
Chimeric antigen receptor T cell (CART) therapy represents a novel and a paradigm-shifting approach to treating cancer. Recent clinical successes have widened the applicability of CD19 CART cells for the treatment of relapsed/refractory B-cell NHL, namely tisagenleclucel and axicabtagene ciloleucel. Tisagenleclucel is also approved for relapsed and/or refractory B-ALL up to age 25. CART therapy is associated with unique and potentially life-threatening toxicities, notably cytokine release syndro ...[more]
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