Ontology highlight
ABSTRACT:
SUBMITTER: Walker CJ
PROVIDER: S-EPMC6825549 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Walker Christopher J CJ Kohlschmidt Jessica J Eisfeld Ann-Kathrin AK Mrózek Krzysztof K Liyanarachchi Sandya S Song Chi C Nicolet Deedra D Blachly James S JS Bill Marius M Papaioannou Dimitrios D Oakes Christopher C CC Giacopelli Brian B Genutis Luke K LK Maharry Sophia E SE Orwick Shelley S Archer Kellie J KJ Powell Bayard L BL Kolitz Jonathan E JE Uy Geoffrey L GL Wang Eunice S ES Carroll Andrew J AJ Stone Richard M RM Byrd John C JC de la Chapelle Albert A Bloomfield Clara D CD
Clinical cancer research : an official journal of the American Association for Cancer Research 20190802 21
<h4>Purpose</h4>Uniparental disomy (UPD) is a way cancer cells duplicate a mutated gene, causing loss of heterozygosity (LOH). Patients with cytogenetically normal acute myeloid leukemia (CN-AML) do not have microscopically detectable chromosome abnormalities, but can harbor UPDs. We examined the prognostic significance of UPDs and frequency of LOH in patients with CN-AML.<b>Experimental Design:</b> We examined the frequency and prognostic significance of UPDs in a set of 425 adult patients with ...[more]