Ontology highlight
ABSTRACT:
SUBMITTER: Drago JZ
PROVIDER: S-EPMC6825550 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Drago Joshua Z JZ Formisano Luigi L Juric Dejan D Niemierko Andrzej A Servetto Alberto A Wander Seth A SA Spring Laura M LM Vidula Neelima N Younger Jerry J Peppercorn Jeffrey J Yuen Megan M Malvarosa Giuliana G Sgroi Dennis D Isakoff Steven J SJ Moy Beverly B Ellisen Leif W LW Iafrate A John AJ Arteaga Carlos L CL Bardia Aditya A
Clinical cancer research : an official journal of the American Association for Cancer Research 20190801 21
<h4>Purpose</h4>While <i>FGFR1</i> amplification has been described in breast cancer, the optimal treatment approach for <i>FGFR1</i>-amplified (FGFR1<sup>+</sup>) metastatic breast cancer (MBC) remains undefined.<b>Experimental Design:</b> We evaluated clinical response to endocrine and targeted therapies in a cohort of patients with hormone receptor-positive (HR<sup>+</sup>)/HER2<sup>-</sup> MBC and validated the functional role of <i>FGFR1</i>-amplification in mediating response/resistance to ...[more]