The genetic polymorphisms of ZC3HC1 and SMARCA4 are associated with hypertension risk.

ABSTRACT: AIM:In this study, we aimed to evaluate the association between genetic variants of ZC3HC1 and SMARCA4 and hypertension risk in the Chinese Han population. METHODS:The Agena MassAssary platform was used to determine the genotypes of eight SNPs in ZC3HC1 and SMARCA4 from 350 hypertension patients and 483 healthy controls. Chi-squared tests and genetic model were used to evaluate the associations. Odds ratios and 95% confidence intervals were calculated using unconditional logistic regression. The statistical power of this study was estimated through the Power and Sample Size Calculation online software. RESULT:In the genetic model analysis, we identified that the SNP of rs1464890 in ZC3HC1 was associated with a 0.68-fold decreased risk of hypertension in the codominant model and 0.65-fold decreased risk in the dominant model. Rs4507692 in ZC3HC1 was associated with a 0.69-fold decreased risk of hypertension in the codominant model and 0.66-fold decreased risk in the dominant model. The genotype "G/A-A/A" of rs11879293 and the genotype "G/T-T/T" of rs1122608 in SMARCA4 were significantly associated with decreasing the hypertension risk. In addition, the "Ars2242487 Trs1464890 Trs4507692 " ZC3HC1 haplotype was associated with a decreased risk of hypertension. CONCLUSION:The present study suggested that ZC3HC1 and SMARCA4 polymorphism may conducive to play a protective role against the hypertension risk.

SUBMITTER: Ma H 

PROVIDER: S-EPMC6825853 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature