Ontology highlight
ABSTRACT:
SUBMITTER: Jones DL
PROVIDER: S-EPMC6826010 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Jones Dakota L DL Haak Andrew J AJ Caporarello Nunzia N Choi Kyoung M KM Ye Zhenqing Z Yan Huihuang H Varelas Xaralabos X Ordog Tamas T Ligresti Giovanni G Tschumperlin Daniel J DJ
Journal of cell science 20191018 20
Tissue fibrosis is a chronic disease driven by persistent fibroblast activation that has recently been linked to epigenetic modifications. Here, we screened a small library of epigenetic small-molecule modulators to identify compounds capable of inhibiting or reversing TGFβ-mediated fibroblast activation. We identified pracinostat, an HDAC inhibitor, as a potent attenuator of lung fibroblast activation and confirmed its efficacy in patient-derived fibroblasts isolated from fibrotic lung tissue. ...[more]