Ontology highlight
ABSTRACT:
SUBMITTER: Esposito Abate R
PROVIDER: S-EPMC6826724 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Esposito Abate Riziero R Pasquale Raffaella R Sacco Alessandra A Piccirillo Maria Carmela MC Morabito Alessandro A Bidoli Paolo P Finocchiaro Giovanna G Chiari Rita R Foltran Luisa L Buosi Roberta R Tiseo Marcello M Giannetta Laura L Battiloro Ciro C Fasola Gianpiero G Romano Gianpiero G Ciuffreda Libero L Frassoldati Antonio A de Marinis Filippo F Cappuzzo Federico F Normanno Nicola N
Cancers 20190925 10
The ICARUS trial is a phase II, open label, multicenter, single arm study conducted to investigate the efficacy, safety, and tolerability of a rechallenge treatment with the first-generation tyrosine kinase inhibitor (TKI) gefitinib in advanced non-small-cell lung cancer (NSCLC) patients carrying activating mutations of the epidermal growth factor receptor (<i>EGFR</i>). The ICARUS trial enrolled 61 patients who were rechallenged with gefitinib at progression after second-line chemotherapy. Seru ...[more]