Ontology highlight
ABSTRACT:
SUBMITTER: Zerdes I
PROVIDER: S-EPMC6827034 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zerdes Ioannis I Wallerius Majken M Sifakis Emmanouil G EG Wallmann Tatjana T Betts Stina S Bartish Margarita M Tsesmetzis Nikolaos N Tobin Nicholas P NP Coucoravas Christos C Bergh Jonas J Rassidakis George Z GZ Rolny Charlotte C Foukakis Theodoros T
Cancers 20191001 10
Signal transducer and activator of transcription 3 (STAT3) is an oncogene and multifaceted transcription factor involved in multiple cellular functions. Its role in modifying anti-tumor immunity has been recently recognized. In this study, the biologic effects of STAT3 on immune checkpoint expression and anti-tumor responses were investigated in breast cancer (BC). A transcriptional signature of phosphorylated STAT3 was positively correlated with PD-L1 expression in two independent cohorts of ea ...[more]