Ontology highlight
ABSTRACT:
SUBMITTER: Autin P
PROVIDER: S-EPMC6827107 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Autin Pierre P Blanquart Christophe C Fradin Delphine D
Cancers 20191010 10
Over recent decades, it has become clear that epigenetic abnormalities are involved in the hallmarks of cancer. Histone modifications, such as acetylation, play a crucial role in cancer development and progression, by regulating gene expression, such as for oncogenes or tumor suppressor genes. Therefore, histone deacetylase inhibitors (HDACi) have recently shown efficacy against both hematological and solid cancers. Designed to target histone deacetylases (HDAC), these drugs can modify the expre ...[more]