Experimental ischemic stroke induces long-term T cell activation in the brain.
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ABSTRACT:
SUBMITTER: Xie L
PROVIDER: S-EPMC6827125 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Experimental ischemic stroke induces long-term T cell activation in the brain.
Xie Luokun L Li Wenjun W Hersh Jessica J Liu Ran R Yang Shao-Hua SH
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20180810 11
Mounting evidence has demonstrated that both innate and adaptive immune cells infiltrate into the brain after ischemic stroke. T cell invasion has been found in the ischemic region up to one month post experimental ischemic stroke and has been shown to persist for years in stroke patients. However, the function and phenotypic characteristics of the brain invading T cells after ischemic stroke have not been investigated. In the current study, we determined the function of brain invading T cells i ...[more]
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