Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake.
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ABSTRACT:
SUBMITTER: Heurling K
PROVIDER: S-EPMC6827127 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
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Regional times to equilibria and their impact on semi-quantification of [<sup>18</sup>F]AV-1451 uptake.
Heurling Kerstin K Smith Ruben R Strandberg Olof T OT Schain Martin M Ohlsson Tomas T Hansson Oskar O Schöll Michael M
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20180803 11
The semi-quantitative estimate standardised uptake value ratios (SUVR) correlate well with specific binding of the tracer expressed as distribution volume ratios (DVR) for the tau positron emission tomography tracer [<sup>18</sup>F]AV-1451 uptake and are therefore widely used as proxy for tracer binding. With regard to tracer kinetic modelling, there exists a time point when SUVR deviates minimally from DVR, occurring when the specific binding reaches a transient equilibrium<i>.</i> Here, we hav ...[more]
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