Cerebrospinal fluid and plasma neurofilament light relate to abnormal cognition.

ABSTRACT:

Introduction

Neuroaxonal damage may contribute to cognitive changes preceding clinical dementia. Accessible biomarkers are critical for detecting such damage.

Methods

Plasma and cerebrospinal fluid (CSF) neurofilament light (NFL) were related to neuropsychological performance among Vanderbilt Memory & Aging Project participants (plasma n = 333, 73 ± 7 years; CSF n = 149, 72 ± 6 years) ranging from normal cognition (NC) to mild cognitive impairment (MCI). Models adjusted for age, sex, race/ethnicity, education, apolipoprotein E ε4 carriership, and Framingham Stroke Risk Profile.

Results

Plasma NFL was related to all domains (P values ≤ .008) except processing speed (P values ≥ .09). CSF NFL was related to memory and language (P values ≤ .04). Inter

SUBMITTER: Osborn KE 

PROVIDER: S-EPMC6827361 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature