Organophosphate pesticides exposure in pregnant women and maternal and cord blood thyroid hormone concentrations.

ABSTRACT:

Background

Animal studies suggest that organophosphate (OP) pesticides exposure affects thyroid function, but evidence in humans remains sparse and inconclusive. Gestational exposure is of particular interest, since thyroid hormone is essential for fetal brain development. OP pesticides are able to cross the placental and blood-brain barrier and may interfere with fetal development processes regulated by thyroid hormone.

Objective

To investigate the association of gestational OP pesticides exposure during pregnancy with maternal and cord blood thyroid hormone concentrations.

Methods

This study was embedded within Generation R (Rotterdam, the Netherlands), a prospective population-based birth cohort. Mother-child pairs with OP pesticides assessment and maternal (N = 71

SUBMITTER: Mulder TA 

PROVIDER: S-EPMC6827719 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature